A combination of herbal compound (SPTC) along with exercise or metformin more efficiently alleviated diabetic complications through down-regulation of stress oxidative pathway upon activating Nrf2-Keap1 axis in AGE rich diet-induced type 2 diabetic mice

Abstract Background SPTC is a mix of four herbal components ( Salvia officinalis , Panax ginseng Trigonella foenum-graeceum and Cinnamomum zeylanicum ) which might be prevented the development AGE rich diet-induced diabetic complication liver injury through activated nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway. Nrf2, as master regulator antioxidant response elements by activating cytoprotective genes expression, decreased oxidative stress that associated with hyperglycemia increases insulin sensitivity. aim this study was to assess whether combination therapy along exercise or metformin moderate related injurie more favorable effects in treatment type 2 mice. Methods We induced diabetes C57BL/6 mice using diet supplementation limitation physical activity. After 16 weeks intervention, fed were compared control Diabetic assigned into seven experimental groups (each group; n = 5): mice, treated (130 mg/kg), Officinalis (65 (300 endurance training, + (130/300 training. Results reduced complications like gain weight, water calorie intake, blood glucose, insulin, GLUT4 content efficiently than each treatment. These combinations improved hemostasis Nrf2 signaling pathway attenuating keap1 protein significantly. Conclusion Eventually, combined novel approach had beneficial prevent hyperglycemia.